DockIt

1IEP · BCR-ABL Kinase

First targeted tyrosine kinase inhibitor for chronic myeloid leukemia.

4HG7 · MDM2

Reactivates p53 tumor suppressor by inhibiting MDM2.

5IKR · COX-2

World's most widely used drug. Inhibits cyclooxygenase.

3RFM · Adenosine A2A Receptor

Blocks adenosine receptors, preventing drowsiness.

1UDT · PDE5

PDE5 inhibitor. Originally for hypertension, famously repurposed.

2HT8 · Neuraminidase

Tamiflu — frontline influenza antiviral.

7BV2 · RNA-dependent RNA Polymerase

COVID-19 drug. Terminates viral RNA replication.

1MUI · HIV-1 Protease

HIV protease inhibitor for antiretroviral therapy.

1JFF · Tubulin

Taxol — stabilizes microtubules to halt cell division.

4CFF · AMPK

Most prescribed diabetes drug globally.

3ERT · Estrogen Receptor α

Selective estrogen receptor modulator for breast cancer.

2RG6 · Acetylcholinesterase

Aricept — first-line Alzheimer's treatment.

3NYA · EGFR Kinase

EGFR inhibitor for non-small cell lung cancer.

3OGP · HMG-CoA Reductase

Lipitor — best-selling drug in history.

2ITO · Dihydrofolate Reductase

Antimetabolite chemotherapy. Blocks folate metabolism.

1PWC · Penicillin-Binding Protein

Started the antibiotic revolution.